This drama is set within the backdrop of an emergency room at a hospital. Kang Jae In (Hwang Jung Eum) is the successor of Ikhyo Foundation, which owns a medical university and five hospitals, but she does not care about the fact that she is the successor. Jae In only cares about her ex-boyfriend.

The love story of Cha Dong Joo, man who's been rendered deaf after an accident but pretends he can hear, and Bong Woo Ri, a woman who's intelligent but pretends she's dim-witted to protect the dignity of her mentally handicapped father.

The drama portrays the life of Lee Kang Mo through his early teens to his early 40s.

Young Eun lived with a family ever since she was an orphan and then fell in love with Do Hyun who is 5 years older than her. However, Do Hyun’s family did not approve of Do Hyun dating Young Eun. As a result, Young Eun eventually left Do Hyun and marries a doctor, Joo Kyung Woo. Although Kyung Woo acts like a gentleman, he is actually a mama’s boy with multiple and complicated personalities. Though he treats Young Eun well, he believes everything his mother tells him and will turn on Young Eun at any moment. Jin Ah is a pediatric medical resident and falls for Do Hyun. But she is unsure of his relationship with Young Eun. Do Hyun decides to marry Jin Ah and after the wedding, Young Eun has had enough of Kyung Woo's mother. She decides to leave Kyung Woo. What will happen between Do Hyun and Young Eun? Will they realize they can't leave without the other?

As of May 2009, the producers announced another change in the format with all four couples departing, cutting down to just one couple and shortening the show to just 60 minutes. The show will now portray a more realistic side to what a marriage is, instead of "the painted image of marriage based on romance". For the first time, a real couple is cast in the show. Guest celebrities are invited to be show's commentators for each episode so that they can share their opinions on marriage on behalf of their age group. Kim Yong Jun and Hwang Jung Eum also do the interview room together dressed in wedding attire.

However, due to low ratings, the show returned to its old format with the addition of a make-believe couple actor Park Jae Jung and After School member Uee on August 2, 2009. For the Chuseok special, Brown Eyed Girls Ga-in & 2AM's Jokwon and SG Wannabe's Lee Seok Hun & host Kim Na Young appeared as two new couples. The episode achieved Season II's highest rating, and Ga-in and Jokwon were announced to be a permanent couple.