A young woman named Ji Hyun was enjoying absolute bliss as she was about to be married with her fiancé, but her perfect life is shattered in a car accident that left her in a coma. She is given a second chance at life by a reaper, but it comes with a condition: she has to find three people outside of her family who would cry genuine tears for her. In order to do this, she borrows the body of Yi Kyung, a part-time employee at a convenience store.

King Jinpyeong did not have any sons to name as a successor to his throne. Thus he named his eldest daughter, Princess Duk Man, to be his successor. The drama will be about the life of Princess Duk Man who was later known as Queen Seon Duk, the first Queen of Silla.

Na In Jung struggles with her love between the rather cold and rebellious Yong Ki and a successful businessman, Soo Hwan. Kang Yong Ki is a pop culture artist. He was separated from his first love, Jo Ann, and still carries the wound that he suffered from their relationship. His half sister is Joo Ran who is married to Soo Hwan. Soo Hwan begins an affair with In Jung but he only has ambition for the CEO position of Yong Ki's father's company. Soon after he discovers that his ambition does not fill the emptiness that he has inside and realizes he needs In Jung. But In Jung and Yong Ki have already fallen in love with each other. Will In Jung go back to her first love or stay with Yong Ki?

Bong Dal Hee (Lee Yo Won) is a first year resident doctor who strives to become a surgeon despite her heart problem. She works under Dr. Ahn Jong Geun (Lee Bum Soo), a cardiac specialist, and even though they don't get off to a good start, the two grow fond of each other as time goes by. Dr. Lee Geon Wook (Kim Min Joon) divorced his wife, Dr. Jo Moon Kyung (Oh Yoon Ah), after he found out that his 6-year-old son was actually fathered by another man before they married. He still has feelings for her, but feels betrayed and cheated. This medical drama portrays the lives of resident doctors, their ups and downs, depicting crisis in a hospital as well as politics among its management staff.