This drama is set within the backdrop of an emergency room at a hospital. Kang Jae In (Hwang Jung Eum) is the successor of Ikhyo Foundation, which owns a medical university and five hospitals, but she does not care about the fact that she is the successor. Jae In only cares about her ex-boyfriend.

Jin Hyuk is a genius neurosurgeon with a cold and severe attitude in his interactions with other people due to his personal pursuit of perfection. Through a mysterious power, Jin Hyuk finds himself transported back in time 150 years. He begins treating people there, but the lack of necessary implements and rudimentary medical knowledge of the period forces him to seek new ways to aid the sick. Through this challenging process, Jin Hyuk eventually becomes a genuine doctor.

A drama that deals with the brain and neurosurgeons.

Lee Kang Hoon (Shin Ha Kyun), who graduated from the top medical school, works at the top hospital, and is the top neurosurgeon around. Basically, he’s Brain No. 1. (And he works on brains, too!) He has ambitions to become the director at his university hospital. He is obsessed with success, which is probably both his greatest flaw and strength, since it makes him steely and fierce.

However, once he meets his sunbae Kim Sang Chul (Jung Jin Young), the prickly genius doctor and world famous neurologist, he turns over a new leaf and becomes a sincere doctor. Seo Joon Suk (Jo Dong Hyuk) is a doctor and will become Lee Kang Hoon’s rival. Yoon Ji Hye (Choi Jung Won) is also a neurosurgeon who grew up in an ordinary family. She is extremely strict in matters of work and study, but has a warm bedside manner with her patients.

A medical investigation drama about forensic doctors solving murder cases.

Han Jin Woo, Korea's top medical examiner, leads a team of experts in conducting a medical crime investigation after strange events and mysterious deaths occur in a hospital. He first clashes with but is later aided by Kang Kyung Hee, an attractive female detective who possesses excellent skill in martial arts and a strong sense of justice.