Kim Yeon Woo is an orthopedic doctor who takes up a new post at Taereung National Village, the training center for national Olympic athletes, after she is fired from her previous job. She becomes romantically involved with Park Ji Heon, a young judo athlete, and Lee Do Wook, the short-tempered, crippled director of the facility who is still haunted by the injury that had cut short his speed-skating career. This is further complicated by the presence of the swimming coach, Hee Young, who becomes her rival for the attentions of Do Wook.

The drama deplicts the life of a talented OB-GYN doctor, Seo Hye Young, and the difficulties she faces with her profession. Her love life takes an unexpected turn when she's pursued by two younger men: one is a pediatrician at her hospital, Lee Sang Shik, and the other is her friend, Wang Jae Suk.

A story about the hospital, Jejoongwon. It was the first modern hospital in Korea established in the Joseon era in 1886.

Jung Ha Yoon is a graduate student who successfully passed the bar exam. However, she is not finished as she wants to be a medical malpractice litigation specialist. She works at a hospital to look to gain experience and there she meets other doctors who work there.

Han Geon Soo is the young clinic owner who tries to protect his clinic from being taken over by loan sharks. He tries his best to save the clinic when uncollected loans are passed on to him after his father's sudden death. Choi Yong Woo is a talented doctor who joins the clinic to return his thanks to Geon Soo's father. Yong Woo is someone that often gets into arguments with patients who want to undergo unnecessary plastic surgery. Yoon Ki Nam is the nurse who forms a love triangle between the two men. Yoon Seo Jin is the manager who obtained her perfect beauty through plastic surgery.

This drama will be about the growth and sufferings of the heart surgeons who work in the thoracic surgery department. Lee Eun Sung graduated from a newly established medical school in the provinces. He applies for a job at the hospital and has high hopes of becoming a great doctor. Nam Hye Suk graduated at top of her medical school. She is an absolute fundamentalist but starts to show her humane side once she gets to know Eun Sung. The problem is Choi Kang Gook just became the new head of the Department of Thoracic and Cardiovascular Surgery. He believes that only doctors can save people's lives and is a genius but he is also a stubborn surgeon who does not care for hospital policies. Only Eun Sung and Hye Suk apply to work in his department.

One day, a famous actor Lee Dong Gwon is admitted into the Hospital for arrhythmia surgery. He immediately falls for Hye Suk, who is his classmate from elementary school. He later gets jealous when he sees that Eun Sung and Hye Suk are getting closer to one another.

Bong Dal Hee (Lee Yo Won) is a first year resident doctor who strives to become a surgeon despite her heart problem. She works under Dr. Ahn Jong Geun (Lee Bum Soo), a cardiac specialist, and even though they don't get off to a good start, the two grow fond of each other as time goes by. Dr. Lee Geon Wook (Kim Min Joon) divorced his wife, Dr. Jo Moon Kyung (Oh Yoon Ah), after he found out that his 6-year-old son was actually fathered by another man before they married. He still has feelings for her, but feels betrayed and cheated. This medical drama portrays the lives of resident doctors, their ups and downs, depicting crisis in a hospital as well as politics among its management staff.