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This drama centers around the scientists at the ‘special infectious disease crisis response team‘ lead by Lee Myung Hyun (Uhm Ki Joon), who investigate a mysterious infection case where the virus has a 100% fatality rate. While investigation, they faces the truth and fights against the power of evil.

Contract employee Ms. Kim (Kim Hye Soo) does everything perfect at work that even her bosses are a little afraid of. She is also shrouded in mystery because her colleagues don’t know her background. Ms. Kim is the center of attention and she is also charismatic and funny. Meanwhile, Jang Kyu Jik (Oh Ji Ho) is a permanent employee in upper management. He finished his MBA in U.S. before returning to Korea. Two of them always argue about everything.

Ji-Hoon (Joo Sang-Wook), who is the leader of Special Affairs Team TEN, has suddenly disappeared. The other members of Team TEN, Do-Sik (Kim Sang-Ho), Ye-Ri (Jo An) and Min-Ho (Choi Woo-Sik) are confused by the situation, but they soon find a message which explains Ji-Hoon's intentions. The members of TEN team chase after the traces of a serial killer known as "murderer F". As they get closer to murderer F, they are in for an unexpected shock.

This drama will tell the story of a father who separates with his daughter, their love, hate and reconciliation. Seo Young (Lee Bo Young) is a tough woman who tries to escape the harsh life of poverty with a strong passion to gain success, overcome her lower status and rise in society. On the road to fullfill her dream, She cuts ties with her poor family and incompetent father (Chun Ho Jin) who still love his daughter despite her bitterness.

Kim Soo-Young (Shin Ha-Kyun) is a newly elected member of the national assembly. He is a member of the conservative New Korea Party. Prior to his election, Kim Soo-Young worked as a judge, but became pressured by higher ups and decided to enter the political world. Now, Kim Soo-Young becomes involved in a tangled situation with national assembly member No Min-Young, who entered the political world after her sister's death. No Min-Young's sister was a presidential candidate. No Min-Young is also a member of the Progressive Labor Party, who only has two members in the national assembly. Kim Soo-Young and No Min-Young then begin to have romantic feelings for each other.

A cruel story within the palace that depicts the battles between concubines in the palace who turns to the dark side in their bid to gain love from the king and power. It will centers around the beautiful but evil royal concubine Jo So Yong (Kim Hyun Joo) as she tries to gain the attention of King In Jo (Lee Duk Hwa) with her beauty and wit to control the power of the Joseon. When she succeeds, there is a bloody battle over the power she receives. She used to be of low class by birth, but she used her extraordinary beauty to get favor of King In Jo and came between King In Jo and Crown Prince So Hyun (Jung Sung Woon).

A drama which drily draws the bluff and fact of the middle class which desires the high class. It will talk about the reality of a middle class family and their money problems, as well as love and marriage.

Mong Hee and Yoo Na (both played by Han Ji Hye) are two different woman who look exactly the same. Mong Hee, is street salesperson who is cheerful and hopeful. She dreams of being a jewelry designer. On the other hand, Yoo Na is a cold modern woman who is a daughter of a rich family.

Park Hyun Soo (Yun Jung Hoon) is the CEO of a large jewelry company, owned by his parents while constantly compete with his brother, Park Hyun Joon (Lee Tae Sung), for the CEO position. Park Hyun Soo is going through a divorce from his ex-wife, Yoo Na. He then will meet and fall in love with Mong Hee who looks exactly like his ex-wife.